Abstract
The application of Miswak (Salvadora persica) in healthy children was investigated to identify the oral microbiota associated with risk factors for type II diabetes mellitus (T2DM). Deep sequencing of the bacterial 16S rDNA V3–V4 regions was conducted on oral microbiome samples obtained prior to and following swaking. The KEGG database and PICRUSt analysis indicated that swaking affected functional pathways, resulting in an enrichment of transport pathways and a decrease in the risk factor associated with the T2DM pathway. Seven operational taxonomic units (OTUs), comprising the uncharacterized species Prevotella, Atopobium, Actinomyces, Lactobacillus, Neisseria bacilliformis, Actinomycetaceae, and TM7-3, were associated with type 2 diabetes mellitus (T2DM). Swaking markedly diminished the prevalence of Prevotella, Atopobium, and Actinomyces, indicating that the oral microbiome may affect systemic inflammation via the oral-gut axis. These findings underscore the potential of swaking to mitigate T2DM risk factors through the modulation of particular oral microbiota.
First Page
54
Last Page
70
Recommended Citation
Bahieldin, Ahmed; Sabbagh, Heba J.; Alshehri, Mohammed H; Algarni, Abdullah M.; Aljahdali, Naif; Asir, Ibrahim M.; Alzahrani, Khalid Mohammed; Almhwary, Awad S.; Alzaghabi, Fatemah Saleh; Alsahafi, Abdullah Jaber; Alshehri, Amjed S; Alzahrani, Ali Ahmed; Alotaibi, Faisal M.; Alghamdi, Mohammed A.; Almutairi, Abdulwahab S.; and Edris, Sherif
(2025)
"Salvadora Persica’s Effects on Oral Microbiota and Possible Pathophysiological Links to Type II Diabetes Mellitus Risk Factors,"
The Journal of King Abdulaziz University: Science: Vol. 35:
Iss.
2, Article 4.
DOI: https://doi.org/10.64064/1658-4252.1009
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This work is licensed under a Creative Commons Attribution 4.0 International License.
