Salvadora Persica’s Effects on Oral Microbiota and Possible Pathophysiological Links to Type II Diabetes Mellitus Risk Factors

Authors

• Ahmed Bahieldin, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Genetics, Faculty of Agriculture, Ain Shams University, Cairo, Egypt AND Centre for Excellence in Bionanoscience Research, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia
• Heba J. Sabbagh, Department of Pediatric Dentistry, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia
• Mohammed H Alshehri, The Ministry of Health, Jeddah, Kingdom of Saudi Arabia
• Abdullah M. Algarni, Public Health Department, Jeddah Health Affairs, The Ministry of Health, Kingdom of Saudi Arabia
• Naif Aljahdali, The Ministry of Health, Jeddah, Kingdom of Saudi Arabia
• Ibrahim M. Asir, Public Health Department, Jeddah Health Affairs, The Ministry of Health, Kingdom of Saudi Arabia
• Khalid Mohammed Alzahrani, The Ministry of Health, Jeddah, Kingdom of Saudi Arabia
• Awad S. Almhwary, The Ministry of Health, Jeddah, Kingdom of Saudi Arabia
• Fatemah Saleh Alzaghabi, Health Programs and Chronic Diseases Department, The Ministry of Health, Jeddah, Kingdom of Saudi Arabia
• Abdullah Jaber Alsahafi, Public Health Department, Jeddah Health Affairs, The Ministry of Health, Kingdom of Saudi Arabia
• Amjed S Alshehri, The Ministry of Health, Jeddah, Kingdom of Saudi Arabia
• Ali Ahmed Alzahrani, The Ministry of Health, Jeddah, Kingdom of Saudi Arabia
• Faisal M. Alotaibi, The Ministry of Health, Jeddah, Kingdom of Saudi Arabia
• Mohammed A. Alghamdi, Laboratory Department, University Medical Services Center, King Abdulaziz University, P.O. Box 80200, Jeddah, 21589, Saudi Arabia
• Abdulwahab S. Almutairi, The Ministry of Health, Jeddah, Kingdom of Saudi Arabia
• Sherif Edris, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Genetics, Faculty of Agriculture, Ain Shams University, Cairo, Egypt AND Centre for Excellence in Bionanoscience Research, King Abdulaziz University, Jeddah, Kingdom of Saudi ArabiaFollow

Abstract

The application of Miswak (Salvadora persica) in healthy children was investigated to identify the oral microbiota associated with risk factors for type II diabetes mellitus (T2DM). Deep sequencing of the bacterial 16S rDNA V3–V4 regions was conducted on oral microbiome samples obtained prior to and following swaking. The KEGG database and PICRUSt analysis indicated that swaking affected functional pathways, resulting in an enrichment of transport pathways and a decrease in the risk factor associated with the T2DM pathway. Seven operational taxonomic units (OTUs), comprising the uncharacterized species Prevotella, Atopobium, Actinomyces, Lactobacillus, Neisseria bacilliformis, Actinomycetaceae, and TM7-3, were associated with type 2 diabetes mellitus (T2DM). Swaking markedly diminished the prevalence of Prevotella, Atopobium, and Actinomyces, indicating that the oral microbiome may affect systemic inflammation via the oral-gut axis. These findings underscore the potential of swaking to mitigate T2DM risk factors through the modulation of particular oral microbiota.

First Page

54

Last Page

70

Recommended Citation

Bahieldin, Ahmed; Sabbagh, Heba J.; Alshehri, Mohammed H; Algarni, Abdullah M.; Aljahdali, Naif; Asir, Ibrahim M.; Alzahrani, Khalid Mohammed; Almhwary, Awad S.; Alzaghabi, Fatemah Saleh; Alsahafi, Abdullah Jaber; Alshehri, Amjed S; Alzahrani, Ali Ahmed; Alotaibi, Faisal M.; Alghamdi, Mohammed A.; Almutairi, Abdulwahab S.; and Edris, Sherif (2025) "Salvadora Persica’s Effects on Oral Microbiota and Possible Pathophysiological Links to Type II Diabetes Mellitus Risk Factors," The Journal of King Abdulaziz University: Science: Vol. 35: Iss. 2, Article 4.
DOI: https://doi.org/10.64064/1658-4252.1009

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